At Merus, we are clinically advancing leading-edge, targeted treatments to address the unmet needs of patients with various types of cancer. Utilizing our proprietary technology platforms, we are developing innovative multispecific antibody therapeutics, referred to as Multiclonics®. Our therapeutic candidates engage cancer antigens and harness the power of the immune system to kill tumor cells in unique and powerful ways by utilizing our proprietary technology platform and deep expertise in oncology. We are currently developing a broad pipeline of wholly owned and licensed Biclonics® drug candidates in the clinic with compelling target combinations and unique mechanisms of action.
 
Medical Affairs is a new function at Merus and you have an opportunity to join us on the ground floor and build a high-functioning medical affairs organization. You will be working in an international cross-functional team, supporting the development of novel bispecific antibody therapeutics. Joining Merus means joining our pursuit to develop advanced therapies that address unmet needs in cancer treatment. The successful candidate will report to the Field Medical Director.

Your Role:

The Medical Science Liaison (MSL) will be responsible for engaging with Healthcare Professionals (HCPs) in their territory through appropriate high-level scientific support for education and scientific exchange.  The MSL will be a conduit for medical affairs communications and interactions for their assigned HCPs. Knowledge of oncology is required; knowledge of NGS testing and companion diagnostics is preferred.
 
In this role you will: 
  • Support study start-up though review of competitive trial landscape, precedent trials; leveraging contacts in medical community w/ prospective PIs, engagement and follow-up with potential sites
  • Expand company knowledge of investigational sites, both current and new, in order to build company network to include knowledge of site capabilities and past performance
  • Inform Clinical Operations when an investigator expresses an interest in becoming a site
  • Develop and execute field medical affairs plan for the assigned territory level in alignment with medical affairs strategies and tactics
  • Serve as a liaison for clinical and scientific information exchange with regional oncologists, pathologists, oncology nurses, NPs, PAs and pharmacists
  • Deliver high quality education and awareness presentations to ensure optimal patient care
  • Obtain, assimilate, organize and report field insights in a concise, clear and compliant manner
  • Provide timely, accurate, specific and balanced responses to professional requests for information in collaboration with medical communications
  • Provide complete and timely documentation of interactions and contacts 
  • Administrative reports such as expense reports and status reports completed in a timely manner
  • Provide reports, assessments and HCP insights in a clear, succinct and timely fashion
  • Maintain and continually develop scientific knowledge of the relevant competitive landscape
  • Attend and participate in all required compliance trainings
  • Follow all laws, rules, regulations, guidance documents, codes, etc. associated or attributed the pharmaceutical industry
  • Attend national, regional and local conferences and symposia in coordination with overarching company objectives
  • Follow all company policies and procedures as well as those of applicable to collaborators and institutions 

Your Profile:

The successful Medical Science Liaison is a proven self-starter with excellent problem-solving skills that meets the following requirement: 
  • M.D., Ph.D., Pharm.D. or NP/PA with appropriate clinical experience and scientific background
  • 2+ years’ oncology clinical experience and 1+ years’ MSL experience in pharmaceutical industry
  • Knowledge of pharmaceutical rules, regulatory law, guidelines and codes (e.g., PhRMA Code)
  • Strong collaboration skills to coordinate efforts and accomplish goals as a team
  • Demonstrate ability to develop trust and maintain integrity with internal and external partners, peers, and others
  • Ensure the attainment of individual objectives and results as well as those for the assigned team
  • Excellent interpersonal, verbal and written communication skills
  • Ability to learn new scientific and technical information quickly
  • Strong computer skills, proficiency in on-line data searches, MS Word, PowerPoint & Excel 
  • Ability to handle and prioritize multiple assignments and to meet deadlines in a fast-paced working environment
  • Travel approximately 50% (car, plane, etc.)

Benefits

We offer a once-in-a-lifetime opportunity to work with some of the best and brightest in the biotech industry. As part or Merus, you’ll get to interact with a great international team of people who love what they do! To top it all, we offer a competitive salary, flexible working hours and a company bonus structure. Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus.   

Merus is seeking a skilled Clinical Data Manager to join our dynamic Biometrics team. With a focus on oncology, this role is pivotal in leading and coordinating the end-to-end quality deliverables of data management activities for one or more clinical trials. This includes study setup, conduct, and closeout, ensuring compliance with GCP and applicable regulatory guidance. Reporting directly to the Vice President of Biometrics, you will play a critical role in maintaining our high standards and driving our clinical research forward. 

Your Role

As a Clinical Data Manager, you will: 

  • Act as the sponsor lead data manager for one or more clinical trials. 
  • Oversee vendors and ensure implementation of Merus standards across trials, ensuring the integration of project protocols into daily operations. 
  • Serve as the primary liaison between CRO Data Management groups and Clinical Trial Teams, facilitating effective communication and collaboration. 
  • Collaborate on CRF design, statistical planning, and Clinical Study Reports to optimize data management strategies. 
  • Ensure the development and maintenance of data management project documentation, perform independent reviews of data management deliverables, and manage the operational and financial aspects of data management tasks. 
  • Identify and manage data management milestones and project risks, ensuring that data management objectives are met with quality and on time. 
  • Act as the clinical data custodian, liaising between vendors, ensuring compliance with regulatory guidelines and documentation requirements, and monitoring the data cleanup process conducted by CROs from study start-up through data archiving. 
  •  Manage existing company standards related to the collection, handling, and review of clinical trial data, and process requests for new standards as needed. 

Your Profile:

If you are driven to achieve, excel in collaborative environments, and are dedicated to advancing cancer treatment, we encourage you to apply. 

Requirements: 
  • A University Degree in Biomedical Sciences or a related field; an Advanced Degree is preferred. 
  • 6-8 years of data management (especially in Oncology), preferably on the sponsor as well as the CRO side. 
  • Industry-level experience with CDISC, CDASH, SDTM, and related industry and health authority initiatives. 
  • Strong leadership skills and the ability to work collaboratively across teams. 
  • Proven ability to manage risks and deliver high-quality clinical data on time and within budget. 
  
This position offers the opportunity to be at the forefront of data management within a company that is passionate about developing advanced therapies for cancer treatment. You will have the chance to work with cutting-edge biometrics applications and software tools, providing expert input and taking a leadership role in shaping the future of clinical data management at Merus.. 

Our Offer:

We offer a once-in-a-lifetime opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll experience a steep learning curve from your very first day in the job. And you’ll get to interact with a great international team of people who love what they do! To top it all, we offer a competitive salary, flexible working hours, an excellent pension scheme, a company bonus and 30 days’ annual leave (based on a full-time position). Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus. 
The pre-clinical team at Merus is looking for an enthusiastic collaborative technician with cell biology skills. The team studies the mechanism of action of our bispecific antibodies and plays an important role in the discovery of ground-breaking new medicines for the treatment of cancer. As a team member you will be part of an international organization where everything you do contributes to our company’s mission: closing in on cancer.

The role:

We are seeking a dedicated Technician – Cell Biology who embodies both expertise and a passion for innovation. In this role, you will join a dynamic team, contributing to the development and execution of sophisticated cell biology experiments. As Technician in the preclinical department, your main tasks and responsibilities will be the following:
  • Carrying out cell-based assays, including primary cell assays and reporter assays
  • Culturing mammalian cell lines, both adherent and suspension cells
  • Carrying out FACS analysis
  • Developing cell-based assays
  • Developing research protocols
  • Documenting laboratory experiments

Your Profile:

The ideal candidate is not only technically proficient but also thrives in a collaborative environment, demonstrating a commitment to quality and a solution-focused approach. Your work will be crucial in advancing our understanding and application of cellular technologies to drive forward our research in novel therapeutics. 

Requirements:
  •  Bachelor’s or Master’s degree in a relevant scientific discipline.
  •  At least 2 years of relevant work experience in cell biology or a related field.
  •  Strong expertise in mammalian cell culture techniques.
  • Demonstrable experience with cell-based assays. Proficiency in flow cytometry, immunocytochemistry, and analytical biochemistry assays is considered a plus.
  • Excellent organizational skills and a detail-oriented approach to laboratory work.

Benefits

We offer a once-in-a-lifetime opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll experience a steep learning curve from your very first day in the job. And you’ll get to interact with a great international team of people who love what they do! To top it all, we offer a competitive salary, flexible working hours, an excellent pension scheme, a company bonus and 30 days’ annual leave (based on a full-time position). Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus.
We are on the lookout for an experienced Clinical Quality Director, GCP. 
 
In this role you will set up and lead the Clinical Quality team that focuses on understanding the evolving regulatory landscape to build and enhance fit for purpose quality foundations that enable Good Clinical Practice (GCP) excellence. The Clinical Quality team strives to ensure that the clinical quality management system (QMS) is optimized to foster a culture where quality innovation matches the company’s cutting-edge and patient-centric science. 
  
This is a strategic role that will define, implement, and optimize risk-based quality strategy in coordination with the Clinical and the Quality team employing a solution-oriented approach to quality management, quality partnership, quality improvement, and quality excellence.  

Your role:

As Clinical Quality Director, GCP you will:  
  • Define, implement, and optimize risk-based quality management plans for clinical assets. 
  • Provide global GCP guidance for cross-functional development teams in order to build robust internal processes that ensure GCP/GVP compliant Sponsor oversight of the conduct of clinical trials. Partner with functional departments (e.g., Biometrics, Clinical Operations, Clinical Development, Safety) to enhance culture of quality. 
  • Host GCP inspections by regulatory authorities. Lead proactive GCP inspection readiness activities globally; Support questions from regulators, review boards, ethics committees, development partners, etc. 
  • Support issue management and corrective/preventive action management activities within company and with external service providers. 
  •  Design and oversee risk-based audit plans which may include but are not limited to internal audits, clinical investigator audits, file audits, system audits, and vendor audits; Conduct and/or oversee audits in accordance with audits plans. 
  •  Plan and conduct efforts to evaluate and improve the clinical QMS inclusive of reporting to leadership stakeholders (e.g., QMS health metrics, prioritized QMS initiatives, internal audits). 
  • Support efforts to identify and implement new technologies to optimize quality (e.g., electronic trial master file safety tools). 
  • Instill a culture for cross-functional review, ownership, management and filing of all documentation (internal and external) within the eTMF that is supportive of a clinical trial 

Your profile:

Our ideal candidate will have experience with hosting GCP health authority inspections (for marketing authorization) & leading the inspection readiness activities that ensure successful outcome of such inspections.   
  
This is then backed up by following experience: 
  • 15 years of GCP quality experience. 
  • Strong understanding of GCP (e.g., ICH GCP E6 R2; 21 CFR parts 11, 50, 54, 56, 312, 314; European Union Clinical Trials Directive). 
  • Understanding of GVP (e.g., European Union Directive 2010/84/EU and current modules) is a plus. 
  •  Understanding of global clinical and safety regulations.  As well as the clinical development lifecycle, ideally for large molecules.  
  • Experience organizing and overseeing GCP audit programs. 
  • Ability to effectively escalate quality concerns to management / leadership in coordination with Clinical Quality leadership 
  • Ability to manage multiple simultaneous projects. 
  • Commitment to diversity, equity, and inclusion. 

Why Merus?

Joining Merus means joining our pursuit to develop advanced therapies that address unmet needs in cancer treatment. Everything we do contributes to our company’s mission: closing in on cancer. 
This is a unique opportunity to join a dynamic and innovative team with high visibility. We offer a competitive salary and benefits package, along with a collaborative and stimulating work environment. If you are skilled and motivated, we would love to hear from you!  

 The Human Resources Team within Merus is responsible for attracting, developing and retaining top talent to help us fulfill our mission. Every day we strive to be an employer of choice and to create and atmosphere in which professionals excel.  

Our small, dedicated team is in charge of all the HR processes and policies for our fast-growing international organization and is always available to address HR needs from managers or individual employees. We like to get the job done, stay pragmatic and have fun while making sure our specialists can focus on what they do best.

 
 

Your Role

As HR Business Partner you advise managers and their teams on how to get the best out of our talents, you will be focusing on the recruitment for our Headquarters, you manage activities during the yearly HR cycle, follow up on Employee Engagement Survey and you enjoy supporting management in their overall HR responsibility. These will be your day-to-day tasks:
 
  • Translating business line developments and objectives into HR actions and policies; 
  • Supporting business in long term strategic workforce planning & development; 
  • Assisting line managers in solving organizational, people & change related issues; 
  • Making analyses and advise on issues related to working conditions and absence, focusing on interventions designed to reduce absence rates. 
  • Talent Acquisition: in close cooperation with our recruiter, hiring managers and external agencies you are able to find and attract talent for our company; 
 

Your Profile

We would like to get in touch with you if you meet the following requirements:
  • You have a Bachelor or Master Degree, for example in HRM or organizational/business studies;
  • You have a solid track record and at least 5 years of experience in the field of HR: People Performance Management, Talent Management and operational expertise as well as strong knowledge of Dutch labour legislation, preferably in Biotech/Life Sciences; 
  • Well-developed analytical skills in combination with a very pragmatic and result-driven approach; 
  • Good command of written and spoken English; (Dutch is a plus)
  • You are able to act as a partner to the business providing swift, efficient and personal guidance to employees and managers; 
  • You have an excellent sense of what the organization needs and are able to communicate this well in an international (matrix) environment. 

Benefits

We offer a once-in-a-lifetime opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll experience a steep learning curve from your very first day in the job. And you’ll get to interact with a great international team of people who love what they do! To top it all, we offer a competitive salary, flexible working hours, an excellent pension scheme, a company bonus and 30 days’ annual leave (based on a full-time position). Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus.
The Clinical Operations team is responsible for all clinical trials we conduct for our product candidates. The team has members residing in the US and in the Netherlands. The position is located in the US (Cambridge). Currently we have four product candidates in ongoing clinical trials for solid tumor cancer patients. 

Key Responsibilities

As (Senior) Clinical Trial Assistant you are part of the global Clinical Operations Team. Your main tasks and responsibilities are the following: 
  •  Maintain and file essential clinical trial documents and completeness check of TMF
  • Responsible for quality check of documents during filing 
  •  General administrative tasks;
  • Set up meetings;
  •  General assistance of the Clinical Operations team (onboarding of new Clinical Operations & Clinical Development team members, preparation of overviews and output, etc); 
  •   Support in vendor and site agreement workflow
  •   Creation of purchase orders and reviewing of invoices for the Clinical Operations and Clinical Development team.

Skills, Knowledge and Expertise

The successful Clinical Trial Assistant will have the following knowledge and expertise: 
  • Advanced (e.g. Masters) degree or equivalent education / degree in life sciences;
  • 2 – 3 years of experience in a similar role;
  • Knowledge of ICH Good Clinical Practice (GCP)
  • You master the English language;
  • You have extensive experience with MS Office (in particular Word, Outlook, Excel and PowerPoint);
  • You are a born organizer and thrive when given the opportunity to help others;
  • You have a high level of quality and an eye for detail;

Please note that this role is an onsite/hybrid role and we will require candidates to be able to travel into the office. Candidates currently not living in the USA or at a reasonable travel distance from Cambridge, Massachusetts, will not be considered for the selection process. 

Our offer

We offer a once-in-a-lifetime opportunity to work with some of the best and brightest in the biotech industry. As part or Merus, you’ll get to interact with a great international team of people who love what they do! To top it all, we offer a competitive salary, flexible working hours and a company bonus structure. Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus. 
We are looking for a highly motivated Senior Technician passionate about making a significant impact.

Join our dynamic Preclinical Research team at Merus, a hub of innovation in the field of cancer treatment.  Within our research department, we pioneer the development of innovative bispecific antibodies aimed at revolutionizing cancer therapy. 

Key Responsibilities

In this pivotal role, you will be at the forefront of conducting experiments for the in-vitro identification and characterization of groundbreaking preclinical drug candidates in our pipeline. 
Your day-to-day tasks will be: 
  • Conduct high-quality experiments under senior team guidance. 
  • Maintain routine tissue culture and cell line management. 
  • Perform antibody screening using cell-based functional assays. 
  • Develop and validate robust cell-based assays to characterize antibody responses. 
  • Assist in developing cell-based and immunoassay methods. 
  • Draft SOPs and protocols, ensuring meticulous documentation in lab notebooks and reports. 
  • Present data and findings at team meetings, collaborating across departments to support R&D goals. 
  • Execute additional duties as required, embracing new techniques and contributing to innovative research. 

Your Profile

We are looking for a candidate with ample experience in cell-based assays, co-culturing and immunohistochemistry. You thrive in dynamic environments, and you have a meticulous eye for detail to every task. Your experience or desire to work in a fast-paced setting underscores your ability to multitask effectively.

Requirements:

  • A BSc or MSc in Cell Biology, Immunology, or related fields. 
  • 2-3 yrs of experience in cell biology techniques and the capability to design and execute experiments independently. 
  • Expertise in immunoassays (ELISA, cytokine release measurement, immunocytochemistry), mammalian tissue culture, and cell-based assays. 
  • Proficiency in 96-well plate handling
  • Strong teamwork and communication abilities, critical thinking, and problem-solving skills. 
  • Familiarity with R&D software, data analysis/reporting tools, and robotics is preferred, alongside a commitment to lab safety.

Benefits

We offer a once-in-a-lifetime opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll experience a steep learning curve from your very first day in the job. And you’ll get to interact with a great international team of people who love what they do! To top it all, we offer a competitive salary, flexible working hours, an excellent pension scheme, a company bonus and 30 days’ annual leave (based on a full-time position). Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus.
 Merus is seeking a Senior/Principal Biostatistician with a robust background in statistics and relevant experience in clinical trials to join our team.  To be based within our dynamic biostatistics function, you will be reporting to a Senior Director of Biostatistics. This position significantly impacts our clinical development activities, including leading the statistical aspects of clinical trials from design through to analysis, ensuring the delivery of high-quality data to support our clinical development programs. 

Your Role

As a Senior Biostatistician at Merus, you will be responsible for all statistical aspects of clinical trials, ensuring methodologies and analyses are robust and aligned with scientific objectives. Your role involves strategic collaboration with cross-functional teams and oversight of CROs to guarantee high-quality statistical deliverables.  

Areas of responsibility:   

  • Serve as the lead statistician for at least one study within our clinical development programs, offering strategic statistical input from trial design to analysis. 
  • Collaborate with cross-functional teams on study design, including sample size, randomization procedures, endpoint selection, and case report form design. 
  • Develop, oversee, and ensure the alignment of Statistical Analysis Plans (SAPs) with study objectives and regulatory compliance. 
  • Oversee CRO deliverables, ensuring the accuracy, quality, and integrity of statistical outputs, including the production of tables, listings, and figures. 
  • Foster collaborative relationships within the clinical department and with external vendors to maintain effective communication and project integrity. 
  • Provide comprehensive statistical support across all phases of clinical trial and project development, including the design of clinical study reports. 

Your Profile:

For this role, we seek a candidate with an advanced degree in statistics or equivalent, with  relevant experience pharma, biotech or CRO. You’ll bring a deep understanding of statistical principles applied to clinical research, proficiency in statistical software (e.g., SAS, R), and a proven ability to communicate complex statistical concepts clearly. Your expertise will be instrumental in driving our research forward, with strong  knowledge of statistical principles in a regulatory environment . 

Requirements:

  • A Master’s degree in statistics or a related field, with at least 5 years of relevant experience in clinical trial analysis.
  • Demonstrated expertise in statistical analysis within clinical or related subjects – experience in oncology is a plus.
  • Familiarity with international standards (ICH, GCP, CDISC) and clinical study regulations.
  • Proficiency in statistical software packages (e.g., SAS, R).
  • Excellent communication and interpersonal skills, with the ability to translate complex statistical concepts for non-technical audiences.
  • Strong leadership and collaboration skills, capable of working on multiple projects simultaneously and under pressure.

Benefits

We offer a once-in-a-lifetime opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll experience a steep learning curve from your very first day in the job. And you’ll get to interact with a great international team of people who love what they do! To top it all, we offer a competitive salary, flexible working hours, an excellent pension scheme, a company bonus and 30 days’ annual leave (based on a full-time position). Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus. 

Are you passionate about antibodies? 
 
 Join the innovative Analytical Support team at Merus, where we’re dedicated to the production and characterization of multispecific antibody formats.  As a Protein Scientist / Antibody Engineer, you will work within project teams, interacting closely with discovery and preclinical scientists.   You’ll play a crucial role in discovering new medicines, working within project teams to create and characterize antibody panels for our groundbreaking assays. This opportunity is for those who are passionate about making a tangible difference in cancer treatments through excellent science and collaborative efforts. 
 

The Role

As a protein scientist your main task is to ensure that our multispecific antibody candidates meet our stringent developability and manufacturability standards. You will take responsibility for producing and characterizing antibody panels to be tested in our assays, playing a crucial role in the development of advanced therapies.  
 
Your responsibilities within the project teams include the following: 
 
  • Design, write and execute experimental studies; 
  • Cloning and production of large antibody panels; 
  • Characterization of antibodies in a range of assays including biophysical, affinity, specificity; 
  • Optimizing antibody sequences for developability and manufacturability; 
  • Delivering quality results in a timely manner; 
  • Propagating skills and knowledge to team members; 
  • Collaboration with external parties. 

Your Profile:

We are seeking a Protein Scientist / Antibody Engineer who is not only technically proficient but also thrives in a collaborative environment. The ideal candidate will possess a quality-driven focus and an ability to efficiently manage multiple projects. Your collaborative spirit will be essential as you work within teams that value scientific excellence and strive to push the boundaries of cancer treatment. You will play a key role in a setting that emphasizes both innovation and the real-world impact of your work, aiming to make significant advancements in the field of cancer therapy. 
 
Knowledge and expertise:  
  • PhD degree in molecular biology or protein chemistry with a minimum of 2 years relevant post-doctoral or industrial experience in protein production and characterization;  
  • Broad experience in protein chemistry, preferably including antibodies; 
  • Demonstrated excellence in the eukaryotic expression, purification (FPLC systems) and analysis of recombinant proteins;  
  • Strong knowledge and technical expertise in protein/antibody characterization including ELISA, FACS, SPR, DSF, SLS/DLS, HPLC (HIC, SEC, Ion Exchange), Mass Spectrometry;   
  • Experience with protein sequence/structure analysis using computational and homology modelling tools such as BioVia Discovery Studio, Pymol, or Schrödinger is preferred; 
 
As this is a laboratory based position- preference will be given to candidates living in the Netherlands- at a commutable distance to Utrecht Science Park.

Benefits

We offer a once-in-a-lifetime opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll experience a steep learning curve from your very first day in the job. And you’ll get to interact with a great international team of people who love what they do! To top it all, we offer a competitive salary, flexible working hours, an excellent pension scheme, a company bonus and 30 days’ annual leave (based on a full-time position). Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus.

Equal Employment Opportunities

Merus is an equal employment opportunity employer that does not discriminate on the basis of actual or perceived race, color, religious creed, national origin, sex (including pregnancy, childbirth, and related medical conditions), sexual orientation, age, ancestry, disability or perceived disability, qualified handicap, gender identity, military status, veteran status, certain criminal records, genetic information or testing, HIV testing, or any other characteristic protected by applicable federal, state or local laws (each, a "Protected Characteristic"). We are dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities and general treatment during employment.

Fraudulent Recruiting Activities

Please be cautious of scam recruitment offers claiming to be from Merus. Such scams may come from various sources, including unsolicited email using Gmail of other non-Merus email addresses or via text. These scams seek to obtain personal information or payment from victims by offering jobs that do not exist. If you have been the victim of such a scam, please report it to Internet Crime Complaint Center(IC3) | Home Page if you are living in the US or report it to the police Aangifte of melding doen | politie.nl if you live in the Netherlands.