Are you ready to join our fight against cancer?
The team:
The Clinical Operations team is responsible for all of the clinical trials we conduct for our product candidates. Currently we have four product candidates in phase I/II studies in oncology, most of them first in class compounds.
This role is US based.
The role:
As a Senior Clinical (Trials) Manager, your main tasks and responsibilities are the following:
- Ensure all operational trial deliverables are met according to timelines, budget, operational procedures, quality/compliance and performance standards under management of the Executive Director of Clinical Operations . This includes the management of Contract Research Organizations (CRO’s);
- Assist in authoring protocol and related documents, development of study tools, guidelines and training materials;
- Manage clinical study material, oversee vendors and other third parties and assist in the implementation plan(s); risk management, oversight management plans, data review processes, TMF review plans and execution, oversight monitoring plans and execution in addition to start-up, execution and close out of clinical trials
- Global clinical trial experience in Oncology across multiple countries / regions
- Manage regular thorough clinical data review (at Merus and through CROs) to ensure it occurs on time, and there is timely query resolution at CROs and clinical sites
- Drive enrollment and recruitment activities and initiatives and provision of information to management team through site enrollment meetings, board slide preparation, management reports and dashboards
- Support the development, management and tracking of trial budgets with the appropriate partners internally and externally;
- Lead internal Operations team meetings and co-lead Clinical Trial Team (CTT) meetings with the CRO
- Participate in the organization and logistics of various trial-related committees;
- Manage site-related issues and procedural questions, support Executive Director & Director of Clinical Operation development of Case Report Forms (CRFs), edit checks, CRF completion guidelines, all plans etc.
- Assist with program level activities (e.g., development of clinical sections of regulatory documents such as Investigators’ Brochures, DSUR/PSUR, IND/NDA submission documents) and provide support, as needed, for HA and/or IRB/IEC inquiries.
- Participation in CRA calls to assist with site follow-up, recruitment, training, protocol deviation finding resolutions, trip report review findings and overall CRA training
- Review of TMF and assistance with remediation of findings along with Clinical Trial Associates (CTAs)
- Manage site engagement and site relationships through communications and visits with clinical sites and cross-functional collaboration with Medical Affairs and Clinical Development
- Review of Monitoring Trip Reports and provision of timely tracking of comments and suggested remediation actions to the CRO
- Participation in oversight monitoring visits at clinical trial sites
Your Profile :
When hiring new employees, we look for people who will fit in well with the collaborative, rigorous, and entrepreneurial spirit of our company – a spirit that drives us to develop advanced therapies that address unmet needs in cancer treatment.
- Advanced (e.g. Masters) degree or equivalent education / degree in life sciences / healthcare;
- 4 – 5 years of experience in clinical development;
- Experience with cross-functional clinical trials, capabilities in supporting operational aspects of clinical trial related activities (planning, executing and reporting) as well as the clinical/scientific aspects;
- Clinical Research Associate experience is strongly preferred and knowledge of how to conduct source data verification (SDV) and how to execute all types of monitoring visits – Site Initiation Visits (SIVs), Interim Monitoring Visits (IMVs) and Close Out Visits (COVs)
- Knowledge of GCP (Good Clinical Practice), comprehensive knowledge of clinical trial design and a good understanding of the overall drug development process; Basic knowledge of oncology, is preferred.
Our offer :
We offer an exciting opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll have the chance to collaborate with an exceptional international team of people who are passionate about what they do. To top it off, we offer a highly competitive total rewards package (benefits and compensation), training that is tailored to your individual development, and career opportunities that match your ambitions. Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus.
Central US location preferred.
At Merus, we are clinically advancing leading-edge, targeted treatments to address the unmet needs of patients with various types of cancer. Utilizing our proprietary technology platforms, we are developing innovative multispecific antibody therapeutics, referred to as Multiclonics®. Our therapeutic candidates engage cancer antigens and harness the power of the immune system to kill tumor cells in unique and powerful ways by utilizing our proprietary technology platform and deep expertise in oncology. We are currently developing a broad pipeline of wholly owned and licensed Biclonics® drug candidates in the clinic with compelling target combinations and unique mechanisms of action.
Medical Affairs is a new function at Merus and you have an opportunity to join us on the ground floor and build a high-functioning medical affairs organization. You will be working in an international cross-functional team, supporting the development of novel bispecific antibody therapeutics. Joining Merus means joining our pursuit to develop advanced therapies that address unmet needs in cancer treatment. The successful candidate will report to the Field Medical Director.
Your role
The Medical Science Liaison (MSL) will be responsible for engaging with Healthcare Professionals (HCPs) in their territory through appropriate high-level scientific support for education and scientific exchange. The MSL will be a conduit for medical affairs communications and interactions for their assigned HCPs. Knowledge of oncology is required; knowledge of NGS testing and companion diagnostics is preferred.
In this role you will:
- Support study start-up though review of competitive trial landscape, precedent trials; leveraging contacts in medical community w/ prospective PIs, engagement and follow-up with potential sites
- Expand company knowledge of investigational sites, both current and new, in order to build company network to include knowledge of site capabilities and past performance
- Inform Clinical Operations when an investigator expresses an interest in becoming a site
- Develop and execute field medical affairs plan for the assigned territory level in alignment with medical affairs strategies and tactics
- Serve as a liaison for clinical and scientific information exchange with regional oncologists, pathologists, oncology nurses, NPs, PAs and pharmacists
- Deliver high quality education and awareness presentations to ensure optimal patient care
- Obtain, assimilate, organize and report field insights in a concise, clear and compliant manner
- Provide timely, accurate, specific and balanced responses to professional requests for information in collaboration with medical communications
- Provide complete and timely documentation of interactions and contacts
- Administrative reports such as expense reports and status reports completed in a timely manner
- Provide reports, assessments and HCP insights in a clear, succinct and timely fashion
- Maintain and continually develop scientific knowledge of the relevant competitive landscape
- Attend and participate in all required compliance trainings
- Follow all laws, rules, regulations, guidance documents, codes, etc. associated or attributed the pharmaceutical industry
- Attend national, regional and local conferences and symposia in coordination with overarching company objectives
- Follow all company policies and procedures as well as those of applicable to collaborators and institutions
Your profile
The successful Medical Science Liaison is a proven self-starter with excellent problem-solving skills that meets the following requirement:
- M.D., Ph.D., Pharm.D. or NP/PA with appropriate clinical experience and scientific background
- 2+ years’ oncology clinical experience and 1+ years’ MSL experience in pharmaceutical industry
- Knowledge of pharmaceutical rules, regulatory law, guidelines and codes (e.g., PhRMA Code)
- Strong collaboration skills to coordinate efforts and accomplish goals as a team
- Demonstrate ability to develop trust and maintain integrity with internal and external partners, peers, and others
- Ensure the attainment of individual objectives and results as well as those for the assigned team
- Excellent interpersonal, verbal and written communication skills
- Ability to learn new scientific and technical information quickly
- Strong computer skills, proficiency in on-line data searches, MS Word, PowerPoint & Excel
- Ability to handle and prioritize multiple assignments and to meet deadlines in a fast-paced working environment
- Travel approximately 50% (car, plane, etc.)
Our offer
We offer an exciting opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll have the chance to collaborate with an exceptional international team of people who are passionate about what they do. To top it off, we offer a highly competitive total rewards package (benefits and compensation), training that is tailored to your individual development, and career opportunities that match your ambitions. Most importantly, you’ll have the chance to join us as we close in on cancer – everything you do matters at Merus.
At Merus, we are advancing leading-edge, targeted treatments using our pioneering multispecific antibody technologies (Multiclonics®), to discover and develop innovative new medicines for patients with cancer. Working at Merus will give you the opportunity to join us in our mission of closing in on cancer. We are a global and diverse team of highly qualified professionals who care deeply about making a difference in patients’ lives. We have bold aspirations, because the need is great and the patients are waiting. Join us and make an impact.
Your role
Merus is seeking a Procurement and Supplier Management Manager to support the Merus teams by providing oversight of the end-to-end Procurement & Supplier Management (PSM) processes, with focus on contract execution and the management of supplier performance by Key Performance Indicators (KPIs). This position will be reporting to the Senior Director, Procurement and Supplier Management.
In this role you will:
- Manage Supplier selection process for assigned departments or categories
- Ensure issues and risks per supplier are collected on an ongoing basis
- Ensure compliance to processes and contracts, including ongoing contract management
- Support the Head of PSM or designee in managing the supplier relationship and performance management activities across multiple service areas
- Support the functional / departmental representatives with setting deliverables for suppliers
- Support the functional / departmental representatives in supplier issue escalations
- Support the Head of PSM or designee in conflict resolution and reconciliation.
- If assigned to Clinical Operations suppliers: Supports the Clinical Manager in the development and maintenance of the Clinical Supplier Management and Oversight Plan (and associated documents) for each study
- Support the review and approval of the Supplier invoices to ensure a smooth processing
- Actively participate in supplier selection related to clinical trials
- Support set up of suppliers including but not limited to purchase order creation / submission / documentation
- Draft contracts by coordinating with the applicable teams on scope and requirements
- Ensure contract drafting, negotiation, approval, execution and filing
- Ad hoc member of the Clinical Trial Team and Vendor Project Management level meetings as applicable
- Support (clinical trial) insurance process by working with the insurance broker, as required
- Support compliance to processes and contracts including ongoing contract management
- Support audits performed at suppliers for supplier qualifications as per GCP
Your profile
We are looking for a candidate with:
- You hold a university degree
- At least four years of relevant experience in procurement and/or supplier management in a life sciences setting
Our offer
We offer an exciting opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll have the chance to collaborate with an exceptional international team of people who are passionate about what they do. To top it off, we offer a highly competitive total rewards package (benefits and compensation), training that is tailored to your individual development, and career opportunities that match your ambitions. Most importantly, you’ll have the chance to join us as we close in on cancer – everything you do matters at Merus.
Merus is seeking a Senior/Principal Biostatistician with a robust background in statistics and relevant experience in clinical trials to join our team. To be based within our dynamic biostatistics function, you will be reporting to a Senior Director of Biostatistics. This position significantly impacts our clinical development activities, including leading the statistical aspects of clinical trials from design through to analysis, ensuring the delivery of high-quality data to support our clinical development programs.
Your Role
As a Senior Biostatistician at Merus, you will be responsible for all statistical aspects of clinical trials, ensuring methodologies and analyses are robust and aligned with scientific objectives. Your role involves strategic collaboration with cross-functional teams and oversight of CROs to guarantee high-quality statistical deliverables.
Areas of responsibility:
- Serve as the lead statistician for at least one study within our clinical development programs, offering strategic statistical input from trial design to analysis.
- Collaborate with cross-functional teams on study design, including sample size, randomization procedures, endpoint selection, and case report form design.
- Develop, oversee, and ensure the alignment of Statistical Analysis Plans (SAPs) with study objectives and regulatory compliance.
- Oversee CRO deliverables, ensuring the accuracy, quality, and integrity of statistical outputs, including the production of tables, listings, and figures.
- Foster collaborative relationships within the clinical department and with external vendors to maintain effective communication and project integrity.
- Provide comprehensive statistical support across all phases of clinical trial and project development, including the design of clinical study reports.
Your Profile:
For this role, we seek a candidate with an advanced degree in statistics or equivalent, with relevant experience pharma, biotech or CRO. You’ll bring a deep understanding of statistical principles applied to clinical research, proficiency in statistical software (e.g., SAS, R), and a proven ability to communicate complex statistical concepts clearly. Your expertise will be instrumental in driving our research forward, with strong knowledge of statistical principles in a regulatory environment .
Requirements:
- A Master’s degree in statistics or a related field, with at least 5 years of relevant experience in clinical trial analysis.
- Demonstrated expertise in statistical analysis within clinical or related subjects – experience in oncology is a plus.
- Familiarity with international standards (ICH, GCP, CDISC) and clinical study regulations.
- Proficiency in statistical software packages (e.g., SAS, R).
- Excellent communication and interpersonal skills, with the ability to translate complex statistical concepts for non-technical audiences.
- Strong leadership and collaboration skills, capable of working on multiple projects simultaneously and under pressure.
Benefits
We offer a once-in-a-lifetime opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll experience a steep learning curve from your very first day in the job. And you’ll get to interact with a great international team of people who love what they do! To top it all, we offer a competitive salary, flexible working hours, an excellent pension scheme, a company bonus and 30 days’ annual leave (based on a full-time position). Most importantly, you’ll have the chance to help us close in on cancer – everything you do matters at Merus.
The Global Head of Talent Acquisition leads the strategy and execution of all talent acquisition efforts for Merus, focusing on building a high-performing, scalable recruitment solution that supports growth across key locations, including the US and Europe. This role drives the end-to-end candidate experience, partnering closely with internal stakeholders to ensure the organization attracts, hires, and onboards top talent efficiently and effectively.
Key Responsibilities
Talent Acquisition Leadership & Strategy
- Develop and execute a robust talent acquisition strategy aligned with the global people strategy and business growth plans.
- Lead a high-performing TA function, leveraging both internal resources and external partners to support recruitment needs for US and European locations.
- Build strong relationships with hiring managers and senior leaders to understand business needs and anticipate talent gaps.
- Coach/player mindset, willing to roll up your sleeves and recruit.
- Manage recruitment budgets, vendor partnerships, and optimize recruitment technology and processes.
Candidate Experience & Onboarding
- Ensure a world-class candidate experience throughout the hiring lifecycle by fostering timely communication, transparency, and engagement.
- Oversee the onboarding process to ensure new hires are set up for success, aligned with company culture, and fully integrated into their roles.
- Continuously assess and improve onboarding programs in partnership with HR and business leaders.
Talent Advisor & Business Partner
- Serve as a trusted talent advisor to business leaders, providing workforce planning insights, market intelligence, and recruitment guidance to support strategic decision-making.
- Partner closely with HR Business Partners and senior leadership to ensure talent acquisition supports broader people strategies and business objectives.
- Promote and enable internal mobility by identifying and advocating for existing talent opportunities within the organization to support career growth and retention.
Operational Excellence & Analytics
- Monitor recruitment metrics and analyze data to assess effectiveness, identify bottlenecks, and drive continuous improvement.
- Ensure compliance with employment laws and internal policies throughout the recruitment process.
- Lead employer branding initiatives to enhance Merus’ attractiveness as an employer of choice.
Skills, Knowledge and Expertise
We are looking for a candidate with:
- Bachelor’s degree in Human Resources, Business, or a related field; advanced degree preferred.
- 10+ years of progressive experience in talent acquisition leadership roles, ideally within life sciences, biotech, or similarly regulated, high-growth industries.
- Proven success designing and executing global or multi-location TA strategies with a focus on both candidate experience and business partnership.
- Experience managing recruitment operations leveraging both in-house and external resources.
- Strong relationship-building skills with internal stakeholders and candidates alike.
- Excellent communication, organizational, and analytical skills.
Our offer
We offer an exciting opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll have the chance to collaborate with an exceptional international team of people who are passionate about what they do. To top it off, we offer a highly competitive total rewards package (benefits and compensation), training that is tailored to your individual development, and career opportunities that match your ambitions. Most importantly, you’ll have the chance to join us as we close in on cancer – everything you do matters at Merus.
The Associate Director, U.S. Patent Agent will play a critical role in shaping and protecting the company’s intellectual property portfolio. This individual will support patent prosecution, portfolio management, and broader IP strategy, working closely with cross-functional teams and external counsel. The ideal candidate will have a strong background in U.S. patent law, particularly within the biotech or pharmaceutical sectors, and a passion for collaborating with world-class scientists.
Your role
Key Responsibilities
- Managing the Company’s U.S. patent portfolio, including preparing and prosecuting patent applications and drafting responses to Office Actions.
- Developing and providing internal training on U.S. IP matters.
- Contributing to technology landscape reviews, freedom-to-operate (FTO) assessments, validity analyses, and development of IP opinions.
- Collaborating with R&D and Clinical teams to identify potential new inventions, coordinating patent filings and prosecution, and protecting Company trade secrets.
- Working closely with senior attorneys and external counsel to align U.S. patent prosecution with global IP strategy.
Additional Responsibilities
- Providing U.S.-specific legal guidance in the context of broader IP strategy development.
- Assisting in IP due diligence in connection with existing and prospective collaboration agreements, and business development opportunities.
- Supporting IP litigation efforts, including working with experts, assisting in factual development, deposition and witness preparation, reviewing pleadings, technology review, and development of case strategy.
- Collaborating with senior attorneys and outside counsel on preparation for hearings, court proceedings and motion practice.
- Contributing to the refinement of internal IP processes and policies to support a growing pharmaceutical enterprise
Your profile
- USPTO-registered U.S. Patent Agent with significant experience in biotech/pharma IP prosecution and strategy.
- Advanced degree in biological sciences, immunology, molecular biology, or a related discipline strongly preferred.
- Preferred minimum of 5 years of experience in patent law, preferably within an in-house biotech or pharmaceutical setting.
- Proven track record of working effectively with scientists and legal teams to protect cutting-edge technologies.
- Strong understanding of U.S. IP laws, practices, and procedures, with ability to translate complex scientific concepts into robust IP protections.
- Excellent written and verbal communication skills.
Our offer
We offer an exciting opportunity to work with some of the best and brightest in the biotech industry. As part of Merus, you’ll have the chance to collaborate with an exceptional international team of people who are passionate about what they do. To top it off, we offer a highly competitive total rewards package (benefits and compensation), training that is tailored to your individual development, and career opportunities that match your ambitions. Most importantly, you’ll have the chance to join us as we close in on cancer – everything you do matters at Merus.
